[PMC free article] [PubMed] [Google Scholar] 48. tKO and WT NOD mice, but IL-17 manifestation was improved under inducible Treg skewing conditions in T cells from Smad4 tKO NOD mice. Our results demonstrate that disruption of the Smad4 pathway in T cells of NOD mice raises Teff cell activation resulting in upregulation of Th17 cells, … Continue reading [PMC free article] [PubMed] [Google Scholar] 48